Medicinal leeches ( Hirudo medicinalis) from the family Hirudinidae are a potentially promising alternative because they are commercially available, not easily disturbed by the host animals, feed at much wider range of temperatures, and can yield much larger blood volumes. Moreover, only a limited number of hematological and biochemical parameters can reliably be measured in their blood meal ( 2, 10). Other shortcomings include a narrow range of environmental temperatures acceptable for feeding and a relatively small blood volume that can be collected. Another drawback is that they are nocturnal feeders and, hence, are highly sensitive to disturbance during feeding and usually only parasitise on motionless animals, ideally during the night. However, kissing bugs are not commercially available and their breeding and maintenance are rather difficult. Blood samples obtained by this method were used for measuring hormone levels, collecting genetic material, sexing, monitoring infectious diseases and measuring hematological and biochemical parameters ( 2, 6– 10). Dipetalogaster maxima was the most common kissing bug species used due to its large size and therefore its capacity for extracting up to 1 ml of blood. The applicability of kissing bugs-blood-sucking insects from the hemipteran subfamily Triatominae-for non-invasive blood sampling has previously been described ( 2, 6– 11). ![]() Therefore, non-invasive blood sampling is a promising tool for blood sample collection with a potential to substantially improve animal welfare in zoos, conservation programmes, and ecophysiological research in animal populations ( 1– 5). Manual restraint is possible in some species, but it carries a high risk of injuries and intense stress for sampled animals. However, blood sampling is a challenging clinical procedure in such conditions, with anesthesia needed in most cases. Veterinary health assessment of animals in zoological collections or in semi-wild and wild conditions requires collection of blood samples for variety of qualitative and quantitative analyses, such as hematological, biochemical, genetic and endocrinological profiling, or screening of pathogenes causing infectious diseases. This opens new opportunities for a significant improvement to animal welfare in zoological gardens, conservation programmes, and ecophysiological research, where quantification of blood parameters is often needed. Our data thus suggest that medicinal leeches can be used as a reliable non-invasive and stress-reducing alternative to standard venipuncture, even for quantitative assays. As the parameter alterations and correlations were similar among species, simple cross-species regression formulas were sufficient to correct the alterations, thereby ensuring good repeatability between leeches and venipuncture in most parameters. Although most hematological and biochemical parameters were significantly altered in leech-derived samples, their values showed strong ( r = 0.62–0.79 10/24 parameters) to very strong ( r > 0.8 13/24 parameters) correlations with venipuncture in all blood parameters, except for sodium ( r = 0.39). The leeches drew up to 20 ml of blood in 20 to 55 min. Medicinal leeches were manually applied on 67 zoo animals of eleven species, and control blood samples were obtained by venipuncture of the jugular vein. Hence, the aim of this study was to evaluate the suitability of the leech blood sampling method for quantification of hematological and biochemical parameters. Blood sampling using medicinal leeches ( Hirudo medicinalis) represents a promising non-invasive alternative to venipuncture however, leech blood meal was to date used only for qualitative analyses such as genetic or serological screenings. Although manual restraint or anesthesia are usually possible, they entail intense stress and a high risk of injuries or organ failure.
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![]() OfficeWork is your private online disk area where you can run the most relevant Owncloud free applications like a Task manager, a Calendar, a Contact manager, a Document Editor, a Presentation Editor and a Spreadsheet Editor to modify PDF, TXT, DOCX, XLSX, XLS, PPTX, CSV, ODT, or HTML files. It is an adaptation of the IMGLY PhotoEditor. PhotoStudio also allows you to take pictures from your PC or laptop camera, apply adjustments like brightness, contrast or clarity and include Stickers. It includes a photo editing area with a multitude of editing features, effects, handcrafted filters and assets. PhotoStudio is an online photo editor to modify your images, photos and graphics. It is an adaptation of the Beautiful audio editor. It contains a lot of options to load, split, trim, import, export, duplicate, modify the speed, increase the volume, merge … audio files. It is an adaptation of the Mozilla Popcorn Maker.ĪudioStudio is an online audio editor to create or modify any music or audio file. MovieStudio is an online movie maker that allows you to make movies, edit videos, record videos, and modify them overlaying another videos, audios, images, and texts. All of them online applications hosted in RedcoolMedia. Among the different web applications available, you can find MovieStudio, AudioStudio, PhotoStudio, PDFOffice and OfficeWork. RedcoolMedia offers multiple web applications and the only requirement is having an Internet connection, which means that you won’t have to worry about disk space or continuous installations. Make sure the picture is truly locked before starting with the sound. It’s relatively easy to drop some frames in a video edit, but in the audio world with the importance of sound flows, to re-edit and re-mix can be anything from a light headache to almost impossible, especially in Logic where you cannot make a reconform. Picture lock does not mean “mostly picture locked”. Now you can use the android app from your computer by opening the emulator software.Picture locked reference video with embedded audio in Apple ProRes 422 Proxy 720p/1080p format. This will start the app installation process.įollow the steps to complete APK installation as like you do in your phone.Ĭongratulations. Once you download the emulator software, you can install it as you install any other computer software by double clicking and following the steps.Īfter installing the emulator, open it and drag and drop the downloaded APK file into the software screen. You can download it using the link given below, after the instructions. It is totally free to download and use it. BlueStacks is one of the most used android emulator. We have given step by step instructions below on how to install and use android apps in PC.įirst we need to download and install an android emulator. To use android app from your computer, you will need an android emulator software that acts as a virtual phone. How to download X2Pro Audio Convert android app for PC (Windows Computer / Mac)? Once the installation is complete, you can start using the app as you normally do. It will start to show the installation prompt that asking for permissions and you can follow the steps to install it. Once you complete the above step, you can go to the "Downloads" in your browser and tap the downloaded APK file once. Open Menu > Settings > Security > and check Unknown Sources to allow your phone to install apps from sources other than the Google Play Store. To enable this, the steps are mostly similar to the below. Once the download is complete, you can find the APK in "Downloads" section in your browser.īefore you can install it on your phone you will need to make sure that third-party apps are allowed on your device. You can download X2Pro Audio Convert APK by clicking the above button and that will initiate a download. How to install X2Pro Audio Convert APK from your android phone? But we strongly recommend not to download from any third-party sources.Īlways download android from Google Play store, unless they don't have the app you're looking for. We have added a button above to download X2Pro Audio Convert APK file. You can download any android app's APK from many sources such as ApkMirror, ApkPure etc. Where can I download X2Pro Audio Convert APK file? ![]() Your apps will not be updated automatically as Google play store usually don't have access to it. ![]() So can be harmful to your phone.ĪPK files can have viruses that will steal data from your phone or corrupt your phone. So you can uninstall and re-install as many as times without needing to download.ĭownloading apps from third-party sources usually are not verified by Google. You will have a APK file in your memory card / system memory once you download. They may have app archives of most versions and you can download the one you may need.ĭownloading is instant unlike play store, no need to wait for the verifcation process etc. You can download any version of the app directly from third-party websites. What are the advantages & disadvantages of downloading APK directly? You will not see the file directly when you download it from play store. At times you may want to download APK files from other sources directly. When you download an app from Google play store, it is downloaded and installed in APK format. If you have any issues or problems in downloading or installing, please post a comment below and someone from our community may help you to fix it quickly.ĪPK stands as an abbreviation for Android Package Kit. Android operating system uses its own type of installation format, as like windows softwares have. ![]() She spent over an hour playing them, one by one, to make sure she bought the right one just for her! Unless someone is here to look at an accordion, I keep them in their cases to protect them from dust. I recently brought out these accordions for a customer who was thinking of buying one. Vital Care Dog Grooming Petco Pay Self-Serve. ![]() I love repairing accordions! Here’s the story of how I started repairing and why I repair accordions. Track Order Returns Shipping Info Recalls & Advisories Pet Store Locator Services. Please leave a message with your phone number I check voicemail daily and will return your call ASAP. Accordion Man is here to buy or swap your accordion or to sell you one There is a wide selection of acoustic and midi models to choose from. You can reach me at: email: (This is the best way to reach me) phone: 91. Whether you’re thinking of repairing your accordion or just selling it, I’d like to hear your story. This site describes the accordions I have for sale, and the repair services that I offer. Paul 16436286 Accordion store is his main squeeze Ken Mahler has long known the ins and outs of the business now, with an assist from an old friend, his. Please leave a message with your phone number I check voicemail daily and will return your call ASAP.Įvery accordion has a story! Please click here to read some of my customer’s stories. email: (This is the best way to reach me).This site describes the accordions I have for sale, and the repair services that I offer. I also sell used accordions these have all been refurbished and maintained. Dealer Locator A quality ATV dealer can make all the difference in the world Post a Renli ATV. 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The meanings of light and easy largely overlap however, light stresses freedom from what is burdensome.Ī light teaching load When might simple be a better fit than easy? The sound wave for a single phoneme is easy to map, and all possible. In this page you can discover 10 synonyms, antonyms, idiomatic expressions, and related words for easy-to-read, like:, informative,, readable,, , uncluttered, easy-reference, concise and reader-friendly. ![]() Moving with effortless grace How do facile and easy relate to one another?įacile often adds to easy the connotation of undue haste or shallowness.įacile answers to complex questions In what contexts can light take the place of easy? While all these words mean "not demanding effort or involving difficulty," easy is applicable either to persons or things imposing tasks or to activity required by such tasks.Īn easy college course When is effortless a more appropriate choice than easy?Īlthough the words effortless and easy have much in common, effortless stresses the appearance of ease and usually implies the prior attainment of artistry or expertness. Augean: Requiring so much to complete as to seem impossible. Arduous: Demanding great effort and labor. Full list of synonyms for Easy-to-understand is here. She never really appreciated the depth of the conflict. Ambiguous: Open to multiple interpretations difficult to interpret. What are another words for Easy-to-understand Lowbrow, unsophisticated, popular, shallow. Additional synonyms appreciate to be aware of and understand. Some common synonyms of easy are effortless, facile, light, simple, and smooth. Abstract: Apart from concrete, practical existence.Difficult to understand. Suppose you have a table called sales in the schema owned by the user lion, and you granted the SELECT privilege for the sales table to PUBLIC.Frequently Asked Questions About easy How does the adjective easy contrast with its synonyms? You can say an easy task or a simple task because easy and simple are synonyms. In a distributed database system, synonyms help simplify SQL statements. are words that have the same, or almost the same, meaning as another word. It can be very frustrating to have your reading interrupted by an unknown word. Method 1 Using Context to Define the Word 1 Read the entire sentence. Understand the process of getting a diagnosis, disease management. There are several steps you can take to help you figure out the meaning of a word without a dictionary.
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![]() Of note was that history of prior stroke/transient ischemic attack was higher in the no-diabetes group than in the diabetes group (33% vs. There were fewer female patients with diabetes than without (37% vs. Most of the patients with diabetes did not require insulin (30%), while 6% did. In all, 7,624 of the 21,105 patients in the ENGAGE AF-TIMI 48 trial had diabetes, for a rate of 36%. Key secondary endpoints included in the subanalysis were cardiovascular death, stroke/SEE, major adverse cardiovascular events (MACE, a composite of myocardial infarction, stroke, SEE, or death because of cardiovascular cause or bleeding), and all-cause death. The primary endpoint and the primary safety endpoint of interest were the same as in the main ENGAGE AF-TIMI 48 trial. Next, they analyzed edoxaban concentration, anti–factor Xa activity, and international normalized ratio data and compared outcomes of high-dose edoxaban with those of warfarin. The investigators further stratified patients into insulin-treated and non–insulin treated groups and used multivariate Cox regression models to adjust for baseline characteristics across the groups stratified by diabetes status. The presence or absence of diabetes was determined by the local investigator at randomization. Plitt and colleagues set out to further evaluate outcomes of patients enrolled in the ENGAGE AF-TIMI 48 trial, excluding those who were in the low-dose edoxaban group. is ‘shameful,’ say expertsįor the current subanalysis, Dr. “The lower-dose regimen was not approved because there was less protection from ischemic stroke, compared with warfarin.”Įxtent of insulin rationing in the U.S. “Therefore, the higher dose of edoxaban was approved globally for treating patients with AFib,” Dr. ![]() It also significantly reduced major bleeding, cardiovascular death, and net outcomes. The findings showed that edoxaban was noninferior to warfarin in preventing stroke/SEEs. The primary safety endpoint was major bleeding, as defined by the International Society on Thrombosis and Haemostasis criteria. The median follow-up was 2.8 years, and the primary efficacy endpoint was stroke or systemic embolic events (SEEs). The edoxaban dose was reduced by 50% if creatinine clearance reached 30-50 mL/min, patient weight reached 60 kg or less, or there was concomitant use of a P-glycoprotein inhibitor ( N Engl J Med. In the ENGAGE AF-TIMI 48 trial, 21,105 patients with documented AFib within the previous 12 months were randomized to standard-care warfarin or high-dose edoxaban (60 mg daily) or low-dose edoxaban (30 mg daily). “Recommendations for anticoagulation managements vary based on the presence of additional risk factors and which guidelines are followed.” “Given the complex clinical interactions between AFib and type 2 diabetes, care for these patients remains challenging,” she said. Plitt, a cardiology fellow at Mount Sinai Hospital, New York, noted that, although type 2 diabetes is characterized by a prothrombotic and inflammatory state, the mechanism of action by which hyperglycemia and/or insulin resistance leads to the development of atrial fibrillation (AFib) remains unknown. ![]() The coexistence of and type 2 diabetes further increases thromboembolic risk.”ĭr. “Type 2 diabetes is associated with a twofold increased risk of stroke, and longer duration of diabetes is associated with even higher ischemic event rates. “We know that atrial fibrillation is associated with a fivefold increased risk of stroke,” Anna Plitt, MD, said at the World Congress on Insulin Resistance, Diabetes & Cardiovascular Disease. In addition, the pharmacokinetic and pharmacodynamic profile of the study drug, edoxaban – a novel oral anticoagulant drug and a direct factor Xa inhibitor – was generally similar in patients with and without diabetes. ![]() ![]() “Virgin Media complies with court orders but we strongly believe that tackling the issue of copyright infringement needs compelling legal alternatives, giving consumers access to great content at the right price, to help change consumer behaviour. “As a responsible ISP”, Virgin continued. We’re aware some groups are claiming the attacks are a result of the recent High Court order which requires ISPs to prevent access to The Pirate Bay. Speaking to The Register, they stated that “Our website,, has been the subject of denial of service attacks so we took the site offline for a short period of time. Louis Cardinals, Tampa Bay Rays, Texas Rangers. Virgin’s statement on the attack continues the relatively mature stance they showed with their response to the high court ruling against the Bay. Philadelphia Phillies, Pittsburgh Pirates, San Diego Padres, San Francisco Giants, Seattle Mariners, St. “If you want to help start a tracker, arrange a manifestation, join or start a pirate party, teach your friends the art of bittorrent, set up a proxy, write your political representatives, develop a new p2p protocol, print some pro piracy posters and decorate your town with, support our promo bay artists or just be a nice person and give your mom a call to tell her you love her.” DDOS and blocks are both forms of censorship. “So don’t fight them using their ugly methods. Even if we strongly disagree with them and even if they hate us. We believe in the open and free internets, where anyone can express their views. ![]() We’d like to be clear about our view on this: “Seems like some random Anonymous groups have run a DDOS campaign against Virgin media and some other sites. Yesterday, TPB posted the following on their Facebook page: Interestingly, Anonymous haven’t received support from The Pirate Bay for their actions. TPB is the standard for tracking BitTorrent files and, although it has had its moments when it has been shut down, it always manages to rise back up, victorious. TPB boasts that it is free for your personal use and claims to also be uncensored. “#Anonymous have just taken down #VirginMedia website again”, they posted on Twitter, “because of their involvement in the #Censorship of The Pirate Bay.” You may remember that when fellow filesharing hub Megaupload was taken down earlier this year, Anonymous hacked a series of US government websites in protest. The Pirate Bay works by tracking files that can be downloaded using the BitTorrent protocol. Virgin were the first UK ISP to put a block on the Swedish website, and true to form, Anonymous were quick to take credit for taking their website. Hacking collective Anonymous have taken down Virgin Media’s website, in response to the recent ruling that forced Virgin and every other UK Internet Service Provider to block access to filesharing giants The Pirate Bay. |
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